An ever-decreasing sample volume required for analysis is allowing more and more cell and microbial cultures to be downscaled from Erlenmeyer flasks to microwell plates. Due to the standardised SBS-format of microwell plates automation solutions can be implemented, greatly expanding the possibilities of fast screening and optimisation studies. Initially culturing in microwell plates was limited by a lack of understanding of the hydrodynamics and the lack of good clamp and cover systems. However, now it can be said that there is a large amount of information and hardware available that allows reproducible and scalable culturing in microwell plates that is in-line with shake flasks results. In this article the focus will be on some of the technologies Kuhner Shaker can oer to improve culturing results